Resistance of Mycobacterium tuberculosis to indole 4-carboxamides occurs through alterations in drug metabolism and tryptophan biosynthesis

Tryptophan biosynthesis represents an important potential drug target for new anti-TB drugs. We identified a series of indole-4-carboxamides with potent antitubercular activity. In vitro, Mycobacterium tuberculosis (Mtb) acquired resistance to these compounds through three discrete mechanisms: (1) a...

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Detalles Bibliográficos
Autores principales: Libardo, M. Daben J., Duncombe, Caroline J., Green, Simon R., Wyatt, Paul G., Thompson, Stephen, Ray, Peter C., Ioerger, Thomas R., Oh, Sangmi, Goodwin, Michael B., Boshoff, Helena I.M., Barry, Clifton E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379015/
https://www.ncbi.nlm.nih.gov/pubmed/33765439
http://dx.doi.org/10.1016/j.chembiol.2021.02.023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379015/
https://www.ncbi.nlm.nih.gov/pubmed/33765439
http://dx.doi.org/10.1016/j.chembiol.2021.02.023

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