A Model of Waardenburg Syndrome Using Patient-Derived iPSCs With a SOX10 Mutation Displays Compromised Maturation and Function of the Neural Crest That Involves Inner Ear Development

Waardenburg syndrome (WS) is an autosomal dominant inherited disorder that is characterized by sensorineural hearing loss and abnormal pigmentation. SOX10 is one of its main pathogenicity genes. The generation of patient-specific induced pluripotent stem cells (iPSCs) is an efficient means to invest...

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Detalles Bibliográficos
Autores principales: Wen, Jie, Song, Jian, Bai, Yijiang, Liu, Yalan, Cai, Xinzhang, Mei, Lingyun, Ma, Lu, He, Chufeng, Feng, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379019/
https://www.ncbi.nlm.nih.gov/pubmed/34426786
http://dx.doi.org/10.3389/fcell.2021.720858

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379019/
https://www.ncbi.nlm.nih.gov/pubmed/34426786
http://dx.doi.org/10.3389/fcell.2021.720858

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