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UbiD domain dynamics underpins aromatic decarboxylation

The widespread UbiD enzyme family utilises the prFMN cofactor to achieve reversible decarboxylation of acrylic and (hetero)aromatic compounds. The reaction with acrylic compounds based on reversible 1,3-dipolar cycloaddition between substrate and prFMN occurs within the confines of the active site....

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Detalles Bibliográficos
Autores principales: Marshall, Stephen A., Payne, Karl A. P., Fisher, Karl, Titchiner, Gabriel R., Levy, Colin, Hay, Sam, Leys, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379154/
https://www.ncbi.nlm.nih.gov/pubmed/34417452
http://dx.doi.org/10.1038/s41467-021-25278-z