Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair

Reactive oxygen species (ROS) oxidize cellular nucleotide pools and cause double strand breaks (DSBs). Non-homologous end-joining (NHEJ) attaches broken chromosomal ends together in mammalian cells. Ribonucleotide insertion by DNA polymerase (pol) μ prepares breaks for end-joining and this is requir...

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Detalles Bibliográficos
Autores principales: Jamsen, Joonas A., Sassa, Akira, Perera, Lalith, Shock, David D., Beard, William A., Wilson, Samuel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379156/
https://www.ncbi.nlm.nih.gov/pubmed/34417448
http://dx.doi.org/10.1038/s41467-021-24486-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379156/
https://www.ncbi.nlm.nih.gov/pubmed/34417448
http://dx.doi.org/10.1038/s41467-021-24486-x

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