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Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4
Melanoma cells rely on developmental programs during tumor initiation and progression. Here we show that the embryonic stem cell (ESC) factor Sall4 is re-expressed in the Tyr::Nras(Q61K); Cdkn2a(−/−) melanoma model and that its expression is necessary for primary melanoma formation. Surprisingly, wh...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379183/ https://www.ncbi.nlm.nih.gov/pubmed/34417458 http://dx.doi.org/10.1038/s41467-021-25326-8 |