Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4

Melanoma cells rely on developmental programs during tumor initiation and progression. Here we show that the embryonic stem cell (ESC) factor Sall4 is re-expressed in the Tyr::Nras(Q61K); Cdkn2a(−/−) melanoma model and that its expression is necessary for primary melanoma formation. Surprisingly, wh...

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Detalles Bibliográficos
Autores principales: Diener, Johanna, Baggiolini, Arianna, Pernebrink, Mattias, Dalcher, Damian, Lerra, Luigi, Cheng, Phil F., Varum, Sandra, Häusel, Jessica, Stierli, Salome, Treier, Mathias, Studer, Lorenz, Basler, Konrad, Levesque, Mitchell P., Dummer, Reinhard, Santoro, Raffaella, Cantù, Claudio, Sommer, Lukas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379183/
https://www.ncbi.nlm.nih.gov/pubmed/34417458
http://dx.doi.org/10.1038/s41467-021-25326-8

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