MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer

Prostate cancer (PCa) shows strong dependence on the androgen receptor (AR) pathway. Here, we show that squalene epoxidase (SQLE), an enzyme of the cholesterol biosynthesis pathway, is overexpressed in advanced PCa and its expression correlates with poor survival. SQLE expression is controlled by mi...

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Detalles Bibliográficos
Autores principales: Kalogirou, C., Linxweiler, J., Schmucker, P., Snaebjornsson, M. T., Schmitz, W., Wach, S., Krebs, M., Hartmann, E., Puhr, M., Müller, A., Spahn, M., Seitz, A. K., Frank, T., Marouf, H., Büchel, G., Eckstein, M., Kübler, H., Eilers, M., Saar, M., Junker, K., Röhrig, F., Kneitz, B., Rosenfeldt, M. T., Schulze, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379214/
https://www.ncbi.nlm.nih.gov/pubmed/34417456
http://dx.doi.org/10.1038/s41467-021-25325-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379214/
https://www.ncbi.nlm.nih.gov/pubmed/34417456
http://dx.doi.org/10.1038/s41467-021-25325-9

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