Identification of genetic modifiers of murine hepatic β-glucocerebrosidase activity

The acid β-glucocerebrosidase (GCase) enzyme cleaves glucosylceramide into glucose and ceramide. Loss of function variants in the gene encoding for GCase can lead to Gaucher disease and Parkinson's disease. Therapeutic strategies aimed at increasing GCase activity by targeting a modulating fact...

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Detalles Bibliográficos
Autores principales: Durán, Anyelo, Rebolledo-Jaramillo, Boris, Olguin, Valeria, Rojas-Herrera, Marcelo, Las Heras, Macarena, Calderón, Juan F., Zanlungo, Silvana, Priestman, David A., Platt, Frances M., Klein, Andrés D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379285/
https://www.ncbi.nlm.nih.gov/pubmed/34458595
http://dx.doi.org/10.1016/j.bbrep.2021.101105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379285/
https://www.ncbi.nlm.nih.gov/pubmed/34458595
http://dx.doi.org/10.1016/j.bbrep.2021.101105

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