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Effects of excitotoxicity in the hypothalamus in transgenic mouse models of Huntington disease

Huntington disease (HD) is a fatal neurodegenerative movement disorder caused by an expanded CAG repeat in the huntingtin gene (HTT). The mutant huntingtin protein is ubiquitously expressed, but only certain brain regions are affected. The hypothalamus has emerged as an important area of pathology w...

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Detalles Bibliográficos
Autores principales: Henningsen, Jo B., Soylu-Kucharz, Rana, Björkqvist, Maria, Petersén, Åsa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379469/
https://www.ncbi.nlm.nih.gov/pubmed/34458633
http://dx.doi.org/10.1016/j.heliyon.2021.e07808