Delivering progranulin to neuronal lysosomes protects against excitotoxicity

Loss-of-function mutations in progranulin (GRN) are a major genetic cause of frontotemporal dementia (FTD), possibly due to loss of progranulin’s neurotrophic and anti-inflammatory effects. Progranulin promotes neuronal growth and protects against excitotoxicity and other forms of injury. It is uncl...

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Detalles Bibliográficos
Autores principales: Davis, Skylar E., Roth, Jonathan R., Aljabi, Qays, Hakim, Ahmad R., Savell, Katherine E., Day, Jeremy J., Arrant, Andrew E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379502/
https://www.ncbi.nlm.nih.gov/pubmed/34298019
http://dx.doi.org/10.1016/j.jbc.2021.100993

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379502/
https://www.ncbi.nlm.nih.gov/pubmed/34298019
http://dx.doi.org/10.1016/j.jbc.2021.100993

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