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Mechanisms of impaired mitochondrial homeostasis and NAD(+) metabolism in a model of mitochondrial heart disease exhibiting redox active iron accumulation

Due to the high redox activity of the mitochondrion, this organelle can suffer oxidative stress. To manage energy demands while minimizing redox stress, mitochondrial homeostasis is maintained by the dynamic processes of mitochondrial biogenesis, mitochondrial network dynamics (fusion/fission), and...

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Detalles Bibliográficos
Autores principales: Chiang, Shannon, Braidy, Nady, Maleki, Sanaz, Lal, Sean, Richardson, Des R., Huang, Michael L.-H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379503/
https://www.ncbi.nlm.nih.gov/pubmed/34416478
http://dx.doi.org/10.1016/j.redox.2021.102038