Alzheimer's Aβ assembly binds sodium pump and blocks endothelial NOS activity via ROS-PKC pathway in brain vascular endothelial cells

Amyloid β-protein (Aβ) may contribute to worsening of Alzheimer’s disease (AD) through vascular dysfunction, but the molecular mechanism involved is unknown. Using ex vivo blood vessels and primary endothelial cells from human brain microvessels, we show that patient-derived Aβ assemblies, termed am...

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Detalles Bibliográficos
Autores principales: Sasahara, Tomoya, Satomura, Kaori, Tada, Mari, Kakita, Akiyoshi, Hoshi, Minako
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379508/
https://www.ncbi.nlm.nih.gov/pubmed/34458695
http://dx.doi.org/10.1016/j.isci.2021.102936

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379508/
https://www.ncbi.nlm.nih.gov/pubmed/34458695
http://dx.doi.org/10.1016/j.isci.2021.102936

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