Lentiviral vectors transduce lung stem cells without disrupting plasticity

Life-long expression of a gene therapy agent likely requires targeting stem cells. Here we ask the question: does viral vector transduction or ectopic expression of a therapeutic transgene preclude airway stem cell function? We used a lentiviral vector containing a GFP or cystic fibrosis transmembra...

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Detalles Bibliográficos
Autores principales: Cooney, Ashley L., Thurman, Andrew L., McCray, Paul B., Pezzulo, Alejandro A., Sinn, Patrick L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379527/
https://www.ncbi.nlm.nih.gov/pubmed/34458011
http://dx.doi.org/10.1016/j.omtn.2021.06.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379527/
https://www.ncbi.nlm.nih.gov/pubmed/34458011
http://dx.doi.org/10.1016/j.omtn.2021.06.010

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