PCSK9 deficiency rewires heart metabolism and drives heart failure with preserved ejection fraction

AIMS: PCSK9 is secreted into the circulation, mainly by the liver, and interacts with low-density lipoprotein receptor (LDLR) homologous and non-homologous receptors, including CD36, thus favouring their intracellular degradation. As PCSK9 deficiency increases the expression of lipids and lipoprotei...

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Detalles Bibliográficos
Autores principales: Da Dalt, Lorenzo, Castiglioni, Laura, Baragetti, Andrea, Audano, Matteo, Svecla, Monika, Bonacina, Fabrizia, Pedretti, Silvia, Uboldi, Patrizia, Benzoni, Patrizia, Giannetti, Federica, Barbuti, Andrea, Pellegatta, Fabio, Indino, Serena, Donetti, Elena, Sironi, Luigi, Mitro, Nico, Catapano, Alberico Luigi, Norata, Giuseppe Danilo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Translational Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8380058/
https://www.ncbi.nlm.nih.gov/pubmed/34252181
http://dx.doi.org/10.1093/eurheartj/ehab431

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8380058/
https://www.ncbi.nlm.nih.gov/pubmed/34252181
http://dx.doi.org/10.1093/eurheartj/ehab431

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