Structure-based virtual screening of CYP1A1 inhibitors: towards rapid tier-one assessment of potential developmental toxicants

Cytochrome P450 1A1 (CYP1A1) metabolizes estrogens, melatonin, and other key endogenous signaling molecules critical for embryonic/fetal development. The enzyme has increasing expression during pregnancy, and its inhibition or knockout increases embryonic/fetal lethality and/or developmental problem...

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Detalles Bibliográficos
Autores principales: Goh, Janice Jia Ni, Behn, Julian, Chong, Cheng-Shoong, Zhong, Guorui, Maurer-Stroh, Sebastian, Fan, Hao, Loo, Lit-Hsin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Bioinformatics and Statistics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8380238/
https://www.ncbi.nlm.nih.gov/pubmed/34181028
http://dx.doi.org/10.1007/s00204-021-03111-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8380238/
https://www.ncbi.nlm.nih.gov/pubmed/34181028
http://dx.doi.org/10.1007/s00204-021-03111-2

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