Soluble tumor necrosis factor-alpha-induced hyperexcitability contributes to retinal ganglion cell apoptosis by enhancing Nav1.6 in experimental glaucoma

BACKGROUND: Neuroinflammation plays an important role in the pathogenesis of glaucoma. Tumor necrosis factor-alpha (TNF-α) is a major pro-inflammatory cytokine released from activated retinal glial cells in glaucoma. Here, we investigated how TNF-α induces retinal ganglion cell (RGC) hyperexcitabili...

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Detalles Bibliográficos
Autores principales: Cheng, Shuo, Wang, Hong-Ning, Xu, Lin-Jie, Li, Fang, Miao, Yanying, Lei, Bo, Sun, Xinghuai, Wang, Zhongfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8380326/
https://www.ncbi.nlm.nih.gov/pubmed/34419081
http://dx.doi.org/10.1186/s12974-021-02236-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8380326/
https://www.ncbi.nlm.nih.gov/pubmed/34419081
http://dx.doi.org/10.1186/s12974-021-02236-6

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