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Evaluating Stability and Activity of SARS-CoV-2 PLpro for High-throughput Screening of Inhibitors
Because of the essential roles of SARS-CoV-2 papain-like protease (PLpro) in the viral polyprotein processing and suppression of host immune responses, it is a crucial target for drug discovery against COVID-19. To develop robust biochemical methodologies for inhibitor screening against PLpro, exten...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8380414/ https://www.ncbi.nlm.nih.gov/pubmed/34420183 http://dx.doi.org/10.1007/s12033-021-00383-y |