Cargando…

Cystathionine β-synthase mediated PRRX2/IL-6/STAT3 inactivation suppresses Tregs infiltration and induces apoptosis to inhibit HCC carcinogenesis

BACKGROUND: Hepatocellular carcinoma (HCC) is characterized by inflammation and immunopathogenesis. Accumulating evidence has shown that the cystathionine β-synthase/hydrogen sulfide (CBS/H(2)S) axis is involved in the regulation of inflammation. However, roles of CBS in HCC development and immune e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Yu-Fu, Song, Shu-Shu, Tian, Meng-Xin, Tang, Zheng, Wang, Han, Fang, Yuan, Qu, Wei-Feng, Jiang, Xi-Fei, Tao, Chen-Yang, Huang, Run, Zhou, Pei-Yun, Zhu, Shi-Guo, Zhou, Jian, Fan, Jia, Liu, Wei-Ren, Shi, Ying-Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Basic Tumor Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8380548/ https://www.ncbi.nlm.nih.gov/pubmed/34413167 http://dx.doi.org/10.1136/jitc-2021-003031

Ejemplares similares

Tumor-associated Tregs obstruct antitumor immunity by promoting T cell dysfunction and restricting clonal diversity in tumor-infiltrating CD8+ T cells
por: Noyes, David, et al.
Publicado: (2022)

Tumor-associated neutrophils and macrophages interaction contributes to intrahepatic cholangiocarcinoma progression by activating STAT3
por: Zhou, Zhengjun, et al.
Publicado: (2021)

N-cadherin inhibitor creates a microenvironment that protect TILs from immune checkpoints and Treg cells
por: Sun, Yi, et al.
Publicado: (2021)

Targeting of GSDMD sensitizes HCC to anti-PD-1 by activating cGAS pathway and downregulating PD-L1 expression
por: Lv, Tingting, et al.
Publicado: (2022)

Leveraging the Treg-intrinsic CTLA4–PKCη signaling pathway for cancer immunotherapy
por: Liu, Hsin-Yu, et al.
Publicado: (2021)

EBV-EBNA1 constructs an immunosuppressive microenvironment for nasopharyngeal carcinoma by promoting the chemoattraction of Treg cells
por: Huo, Shaofen, et al.
Publicado: (2020)

Combination of radiotherapy and suppression of Tregs enhances abscopal antitumor effect and inhibits metastasis in rectal cancer
por: Ji, Dengbo, et al.
Publicado: (2020)

Targeting ANXA1 abrogates Treg-mediated immune suppression in triple-negative breast cancer
por: Bai, Fang, et al.
Publicado: (2020)

Single-cell transcriptomics reveals a low CD8(+) T cell infiltrating state mediated by fibroblasts in recurrent renal cell carcinoma
por: Peng, Yu-Lu, et al.
Publicado: (2022)

Treg-selective IL-2 starvation synergizes with CD40 activation to sustain durable responses in lymphoma models
por: Stirm, Kristin, et al.
Publicado: (2023)

Maximizing cancer therapy via complementary mechanisms of immune activation: PD-1 blockade, neoantigen vaccination, and Tregs depletion
por: D'Alise, Anna Morena, et al.
Publicado: (2021)

Genomic profiles and their associations with TMB, PD-L1 expression, and immune cell infiltration landscapes in synchronous multiple primary lung cancers
por: Hu, Chunhong, et al.
Publicado: (2021)

Cystathionine β-synthase affects organization of cytoskeleton and modulates carcinogenesis in colorectal carcinoma cells
por: Liskova, Veronika, et al.
Publicado: (2023)

Implication of (99m)Tc-sum IL-2 SPECT/CT in immunotherapy by imaging of tumor-infiltrating T cells
por: Gao, Yu, et al.
Publicado: (2023)

Loss of host tissue transglutaminase boosts antitumor T cell immunity by altering STAT1/STAT3 phosphorylation in ovarian cancer
por: Sima, Livia Elena, et al.
Publicado: (2021)

Heterologous prime-boost vaccination targeting MAGE-type antigens promotes tumor T-cell infiltration and improves checkpoint blockade therapy
por: McAuliffe, James, et al.
Publicado: (2021)

Polymorphonuclear myeloid-derived suppressor cells and phosphatidylinositol-3 kinase gamma are critical to tobacco-mimicking oral carcinogenesis in mice
por: Nguyen, Khoa A, et al.
Publicado: (2023)

Lack of myeloid cell infiltration as an acquired resistance strategy to immunotherapy
por: Beyranvand Nejad, Elham, et al.
Publicado: (2020)

LRIG2 promotes glioblastoma progression by modulating innate antitumor immunity through macrophage infiltration and polarization
por: Hu, Jinyang, et al.
Publicado: (2022)

Combinatorial immunotherapy induces tumor-infiltrating CD8(+) T cells with distinct functional, migratory, and stem-like properties
por: Van Braeckel-Budimir, Natalija, et al.
Publicado: (2021)

Selectivity of commonly used pharmacological inhibitors for cystathionine β synthase (CBS) and cystathionine γ lyase (CSE)
por: Asimakopoulou, Antonia, et al.
Publicado: (2013)

Interplay between glucocorticoids and tumor-infiltrating lymphocytes on the prognosis of adrenocortical carcinoma
por: Landwehr, Laura-Sophie, et al.
Publicado: (2020)

Paradoxical interaction between cancer and long-term postsepsis disorder: impairment of de novo carcinogenesis versus favoring the growth of established tumors
por: Leite, Caio Abner, et al.
Publicado: (2020)

Low molecular weight heparin synergistically enhances the efficacy of adoptive and anti-PD-1-based immunotherapy by increasing lymphocyte infiltration in colorectal cancer
por: Quan, Yibo, et al.
Publicado: (2023)

Tumor-infiltrating plasmacytoid dendritic cells are associated with survival in human colon cancer
por: Kießler, Maximilian, et al.
Publicado: (2021)

Cystathionine β-Synthase in Physiology and Cancer
por: Zhu, Haoran, et al.
Publicado: (2018)

STAT3 inhibitor Napabucasin abrogates MDSC immunosuppressive capacity and prolongs survival of melanoma-bearing mice
por: Bitsch, Rebekka, et al.
Publicado: (2022)

Wilms tumor reveals DNA repair gene hyperexpression is linked to lack of tumor immune infiltration
por: Higgs, Emily F, et al.
Publicado: (2022)

PD-1 does not mark tumor-infiltrating CD8+ T cell dysfunction in human gastric cancer
por: Shen, Yang, et al.
Publicado: (2020)

HDAC9 deficiency promotes tumor progression by decreasing the CD8(+) dendritic cell infiltration of the tumor microenvironment
por: Ning, Yongling, et al.
Publicado: (2020)

Malignant cell-specific CXCL14 promotes tumor lymphocyte infiltration in oral cavity squamous cell carcinoma
por: Parikh, Anuraag, et al.
Publicado: (2020)

YY1 complex in M2 macrophage promotes prostate cancer progression by upregulating IL-6
por: Chen, Saisai, et al.
Publicado: (2023)

PP4 inhibition sensitizes ovarian cancer to NK cell-mediated cytotoxicity via STAT1 activation and inflammatory signaling
por: Raja, Remya, et al.
Publicado: (2022)

Metformin improves cancer immunotherapy by directly rescuing tumor-infiltrating CD8 T lymphocytes from hypoxia-induced immunosuppression
por: Finisguerra, Veronica, et al.
Publicado: (2023)

Inactivation of interleukin-30 in colon cancer stem cells via CRISPR/Cas9 genome editing inhibits their oncogenicity and improves host survival
por: D'Antonio, Luigi, et al.
Publicado: (2023)

M1(hot) tumor-associated macrophages boost tissue-resident memory T cells infiltration and survival in human lung cancer
por: Garrido-Martin, Eva M, et al.
Publicado: (2020)

GLIS1 intervention enhances anti-PD1 therapy for hepatocellular carcinoma by targeting SGK1-STAT3-PD1 pathway
por: Rong, Dawei, et al.
Publicado: (2023)

DNGR-1 limits Flt3L-mediated antitumor immunity by restraining tumor-infiltrating type I conventional dendritic cells
por: Cueto, Francisco J, et al.
Publicado: (2021)

Immunization with short peptide particles reveals a functional CD8(+) T-cell neoepitope in a murine renal carcinoma model
por: He, Xuedan, et al.
Publicado: (2021)

SOD3 induces a HIF-2α-dependent program in endothelial cells that provides a selective signal for tumor infiltration by T cells
por: Carmona-Rodríguez, Lorena, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_83kuohv803itfohp6dbvo025uk