Potential Therapeutic Role of HDAC Inhibitors in FUS-ALS

Mutations in the FUS gene cause amyotrophic lateral sclerosis (ALS-FUS). However, the exact pathogenic mechanism of mutant fused in sarcoma (FUS) protein is not completely understood. FUS is an RNA binding protein (RBP) localized predominantly in the nucleus, but ALS-linked FUS mutations can affect...

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Detalles Bibliográficos
Autores principales: Tejido, Clara, Pakravan, Donya, Bosch, Ludo Van Den
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8380926/
https://www.ncbi.nlm.nih.gov/pubmed/34434087
http://dx.doi.org/10.3389/fnmol.2021.686995

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8380926/
https://www.ncbi.nlm.nih.gov/pubmed/34434087
http://dx.doi.org/10.3389/fnmol.2021.686995

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