Cargando…

ADAMTS5 in Osteoarthritis: Biological Functions, Regulatory Network, and Potential Targeting Therapies

ADAMTS5 is involved in the pathogenesis of OA. As the major aggrecanase-degrading articular cartilage matrix, ADAMTS5, has been regarded as a potential target for OA treatment. We here provide an updated insight on the regulation of ADAMTS5 and newly discovered therapeutic strategies for OA. Pathoph...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Lejian, Lin, Jiachen, Zhao, Sen, Wu, Jiaqian, Jin, Yongming, Yu, Li, Wu, Nan, Wu, Zhihong, Wang, Yue, Lin, Mao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381022/ https://www.ncbi.nlm.nih.gov/pubmed/34434966 http://dx.doi.org/10.3389/fmolb.2021.703110

Ejemplares similares

ADAMTS6: Emerging roles in cardiovascular, musculoskeletal and cancer biology
por: Mead, Timothy J.
Publicado: (2022)

Regulation of ADAMTS Proteases
por: Rose, Keron W. J., et al.
Publicado: (2021)

In vivo N-Terminomics Highlights Novel Functions of ADAMTS2 and ADAMTS14 in Skin Collagen Matrix Building
por: Leduc, Cédric, et al.
Publicado: (2021)

Peptide-Based Inhibitors of ADAM and ADAMTS Metalloproteinases
por: Pluda, Stefano, et al.
Publicado: (2021)

Adamts10 controls transforming growth factor β family signaling that contributes to retinal ganglion cell development
por: Wareham, Lauren K., et al.
Publicado: (2022)

The role of oxidative stress in the development of knee osteoarthritis: A comprehensive research review
por: Liu, Lin, et al.
Publicado: (2022)

ADAMTS-12: Functions and Challenges for a Complex Metalloprotease
por: Mohamedi, Yamina, et al.
Publicado: (2021)

HOXC13-AS Induced Extracellular Matrix Loss via Targeting miR-497-5p/ADAMTS5 in Intervertebral Disc
por: Jing, Wanli, et al.
Publicado: (2021)

Editorial: ADAM, ADAMTS and Astacin Proteases: Challenges and Breakthroughs in the -Omics Era
por: Yamamoto, Kazuhiro, et al.
Publicado: (2021)

Editorial: ADAM, ADAMTS and astacin proteases: Challenges and breakthroughs in the -Omics era-Volume II
por: Kwok, Hang Fai, et al.
Publicado: (2023)

Integration of Biological Networks for Acidithiobacillus thiooxidans Describes a Modular Gene Regulatory Organization of Bioleaching Pathways
por: Cortés, María Paz, et al.
Publicado: (2020)

Hyperconserved Elements in Human 5′UTRs Shape Essential Post-transcriptional Regulatory Networks
por: Zuccotti, Paola, et al.
Publicado: (2020)

Exploring the active ingredients and potential mechanisms of action of sinomenium acutum in the treatment of rheumatoid arthritis based on systems biology and network pharmacology
por: Gong, Nan, et al.
Publicado: (2023)

Characterization and role exploration of ferroptosis-related genes in osteoarthritis
por: Wang, Xinyu, et al.
Publicado: (2023)

HTR2B and SLC5A3 Are Specific Markers in Age-Related Osteoarthritis and Involved in Apoptosis and Inflammation of Osteoarthritis Synovial Cells
por: Lu, Xin, et al.
Publicado: (2021)

DNA- and RNA-Binding Proteins Linked Transcriptional Control and Alternative Splicing Together in a Two-Layer Regulatory Network System of Chronic Myeloid Leukemia
por: Wang, Chuhui, et al.
Publicado: (2022)

Editorial: Applications of biological networks in biomedicine
por: Maracaja-Coutinho, Vinicius, et al.
Publicado: (2023)

Editorial: Insights into RNA networks and biology
por: Gerber, André P., et al.
Publicado: (2023)

A Potential circRNA-miRNA-mRNA Regulatory Network in Asthmatic Airway Epithelial Cells Identified by Integrated Analysis of Microarray Datasets
por: Chen, Dian, et al.
Publicado: (2021)

Identification and verification of ferroptosis-related genes in the synovial tissue of osteoarthritis using bioinformatics analysis
por: Xia, Lin, et al.
Publicado: (2022)

Regulatory Non-coding RNAs for Death Associated Protein Kinase Family
por: Wang, Qingshui, et al.
Publicado: (2021)

Editorial: In celebration of women in science: RNA networks and biology
por: Piccinini, Anna M., et al.
Publicado: (2023)

Identification of Potential circRNA-microRNA-mRNA Regulatory Network in Skeletal Muscle
por: Das, Arundhati, et al.
Publicado: (2021)

The Novel Regulatory Role of the lncRNA–miRNA–mRNA Axis in Chronic Inflammatory Airway Diseases
por: Qiao, Xin, et al.
Publicado: (2022)

Identification of a Potential miRNA–mRNA Regulatory Network Associated With the Prognosis of HBV-ACLF
por: Ma, Shanshan, et al.
Publicado: (2021)

Cancer-Associated circRNA–miRNA–mRNA Regulatory Networks: A Meta-Analysis
por: Khan, Shaheerah, et al.
Publicado: (2021)

GAL Regulon in the Yeast S. cerevisiae is Highly Evolvable via Acquisition in the Coding Regions of the Regulatory Elements of the Network
por: Rajeshkannan,, et al.
Publicado: (2022)

Toward Modeling Context-Specific EMT Regulatory Networks Using Temporal Single Cell RNA-Seq Data
por: Ramirez, Daniel, et al.
Publicado: (2020)

Corrigendum: Identification of a Potential miRNA-mRNA Regulatory Network Associated With the Prognosis of HBV-ACLF
por: Ma, Shanshan, et al.
Publicado: (2021)

Construction of the miRNA-mRNA Regulatory Networks and Explore Their Role in the Development of Lung Squamous Cell Carcinoma
por: Fan, Xingchen, et al.
Publicado: (2022)

Multimodal ultrasound fusion network for differentiating between benign and malignant solid renal tumors
por: Zhu, Dongmei, et al.
Publicado: (2022)

Long non-coding RNAs play an important regulatory role in tumorigenesis and tumor progression through aerobic glycolysis
por: Fan, Ni, et al.
Publicado: (2022)

Development of Nanomaterials to Target Articular Cartilage for Osteoarthritis Therapy
por: Rao, Chenyu, et al.
Publicado: (2022)

INPP5E and Coordination of Signaling Networks in Cilia
por: Zhang, Renshuai, et al.
Publicado: (2022)

Association of Mental Health-Related Proteins DAXX, DRD3, and DISC1 With the Progression and Prognosis of Chondrosarcoma
por: He, Lile, et al.
Publicado: (2019)

Identification of Potential Genomic Alterations and the circRNA-miRNA-mRNA Regulatory Network in Primary and Recurrent Synovial Sarcomas
por: Yao, Qing, et al.
Publicado: (2021)

Construction and Comprehensive Analysis of a circRNA-miRNA-mRNA Regulatory Network to Reveal the Pathogenesis of Hepatocellular Carcinoma
por: Mo, Meile, et al.
Publicado: (2022)

The Predictive Competing Endogenous RNA Regulatory Networks and Potential Prognostic and Immunological Roles of Cyclin A2 in Pan-Cancer Analysis
por: Chen, Shenyong, et al.
Publicado: (2022)

Modulation of the biological network of lumbar spinal stenosis by Tongdu Huoxue Decoction based on clinical metabolomics
por: Ji, Luhong, et al.
Publicado: (2023)

Learning the Regulatory Code of Gene Expression
por: Zrimec, Jan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ubb76ap08qukbhhqltvs6au1bs