Metformin Attenuates Silica-Induced Pulmonary Fibrosis by Activating Autophagy via the AMPK-mTOR Signaling Pathway

Long-term exposure to crystalline silica particles leads to silicosis characterized by persistent inflammation and progressive fibrosis in the lung. So far, there is no specific treatment to cure the disease other than supportive care. In this study, we examined the effects of metformin, a prescribe...

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Detalles Bibliográficos
Autores principales: Li, Shu-xian, Li, Chao, Pang, Xin-ru, Zhang, Juan, Yu, Gong-chang, Yeo, Abrey J., Lavin, Martin F., Shao, Hua, Jia, Qiang, Peng, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381252/
https://www.ncbi.nlm.nih.gov/pubmed/34434111
http://dx.doi.org/10.3389/fphar.2021.719589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381252/
https://www.ncbi.nlm.nih.gov/pubmed/34434111
http://dx.doi.org/10.3389/fphar.2021.719589

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