p16(INK4a) Regulates Cellular Senescence in PD-1-Expressing Human T Cells

T-cell dysfunction arising upon repeated antigen exposure prevents effective immunity and immunotherapy. Using various clinically and physiologically relevant systems, we show that a prominent feature of PD-1-expressing exhausted T cells is the development of cellular senescence features both in viv...

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Detalles Bibliográficos
Autores principales: Janelle, Valérie, Neault, Mathieu, Lebel, Marie-Ève, De Sousa, Dave Maurice, Boulet, Salix, Durrieu, Ludovic, Carli, Cédric, Muzac, Chloé, Lemieux, Sébastien, Labrecque, Nathalie, Melichar, Heather J., Mallette, Frédérick A., Delisle, Jean-Sébastien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381277/
https://www.ncbi.nlm.nih.gov/pubmed/34434190
http://dx.doi.org/10.3389/fimmu.2021.698565

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381277/
https://www.ncbi.nlm.nih.gov/pubmed/34434190
http://dx.doi.org/10.3389/fimmu.2021.698565

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