Cargando…

p16(INK4a) Regulates Cellular Senescence in PD-1-Expressing Human T Cells

T-cell dysfunction arising upon repeated antigen exposure prevents effective immunity and immunotherapy. Using various clinically and physiologically relevant systems, we show that a prominent feature of PD-1-expressing exhausted T cells is the development of cellular senescence features both in viv...

Descripción completa

Detalles Bibliográficos
Autores principales:	Janelle, Valérie, Neault, Mathieu, Lebel, Marie-Ève, De Sousa, Dave Maurice, Boulet, Salix, Durrieu, Ludovic, Carli, Cédric, Muzac, Chloé, Lemieux, Sébastien, Labrecque, Nathalie, Melichar, Heather J., Mallette, Frédérick A., Delisle, Jean-Sébastien
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381277/ https://www.ncbi.nlm.nih.gov/pubmed/34434190 http://dx.doi.org/10.3389/fimmu.2021.698565

Ejemplares similares

The Notch signaling pathway controls CD8(+) T cell differentiation independently of the classical effector HES1
por: De Sousa, Dave Maurice, et al.
Publicado: (2019)

IL-6 Production by Dendritic Cells Is Dispensable for CD8(+) Memory T-Cell Generation
por: Daudelin, Jean-François, et al.
Publicado: (2013)

Role of NR4A family members in myeloid cells and leukemia
por: Boulet, Salix, et al.
Publicado: (2022)

Role of the Orphan Nuclear Receptor NR4A Family in T-Cell Biology
por: Odagiu, Livia, et al.
Publicado: (2021)

Defining novel parameters for the optimal priming and expansion of minor histocompatibility antigen-specific T cells in culture
por: Janelle, Valérie, et al.
Publicado: (2015)

Strength and Numbers: The Role of Affinity and Avidity in the ‘Quality’ of T Cell Tolerance
por: This, Sébastien, et al.
Publicado: (2021)

T-Cell Immunotherapies Targeting Histocompatibility and Tumor Antigens in Hematological Malignancies
por: Janelle, Valérie, et al.
Publicado: (2020)

CD40-Activated B Cells Can Efficiently Prime Antigen-Specific Naïve CD8(+) T Cells to Generate Effector but Not Memory T cells
por: Mathieu, Mélissa, et al.
Publicado: (2012)

Obesity triggers tumoral senescence and renders poorly immunogenic malignancies amenable to senolysis
por: Fournier, Frédérik, et al.
Publicado: (2022)

Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor
por: Neault, Mathieu, et al.
Publicado: (2012)

CD5 levels define functionally heterogeneous populations of naïve human CD4(+) T cells
por: Sood, Aditi, et al.
Publicado: (2021)

The Rise of FXR1: Escaping Cellular Senescence in Head and Neck Squamous Cell Carcinoma
por: Fernández, Erlinda, et al.
Publicado: (2016)

T-Cell Dysfunction as a Limitation of Adoptive Immunotherapy: Current Concepts and Mitigation Strategies
por: Janelle, Valérie, et al.
Publicado: (2021)

p16INK4a in cellular senescence
por: Simboeck, Elisabeth, et al.
Publicado: (2013)

SOCS1, a novel interaction partner of p53 controlling oncogene-induced senescence
por: Mallette, Frédérick A., et al.
Publicado: (2010)

The Non-Classical MAP Kinase ERK3 Controls T Cell Activation
por: Marquis, Miriam, et al.
Publicado: (2014)

A vlincRNA participates in senescence maintenance by relieving H2AZ-mediated repression at the INK4 locus
por: Lazorthes, Sandra, et al.
Publicado: (2015)

Erratum: A vlincRNA participates in senescence maintenance by relieving H2AZ-mediated repression at the INK4 locus
por: Lazorthes, Sandra, et al.
Publicado: (2015)

Combined PD-L1 and TIM3 blockade improves expansion of fit human CD8(+) antigen-specific T cells for adoptive immunotherapy
por: Lak, Shirin, et al.
Publicado: (2022)

INK4a/ARF-dependent senescence upon persistent replication stress
por: O’Driscoll, Mark
Publicado: (2013)

P16INK4A—More Than a Senescence Marker
por: Safwan-Zaiter, Hasan, et al.
Publicado: (2022)

ZNF768: controlling cellular senescence and proliferation with ten fingers
por: Villot, Romain, et al.
Publicado: (2021)

Translocation of CaMKII to dendritic microtubules supports the plasticity of local synapses
por: Lemieux, Mado, et al.
Publicado: (2012)

p16(INK4a)-induced senescence is disabled by melanoma-associated mutations
por: Haferkamp, Sebastian, et al.
Publicado: (2008)

Expression of the senescence marker p16(INK4a) in skin biopsies of acute lymphoblastic leukemia survivors: a pilot study
por: Marcoux, Sophie, et al.
Publicado: (2013)

EZH2-dependent chromatin looping controls INK4a and INK4b, but not ARF, during human progenitor cell differentiation and cellular senescence
por: Kheradmand Kia, Sima, et al.
Publicado: (2009)

Cellular senescence mediated by p16(INK4A)-coupled miRNA pathways
por: Overhoff, Marita G., et al.
Publicado: (2014)

MSK1 triggers the expression of the INK4AB/ARF locus in oncogene-induced senescence
por: Culerrier, Raphaël, et al.
Publicado: (2016)

Senescence promotes in vivo reprogramming through p16(INK) (4a) and IL‐6
por: Mosteiro, Lluc, et al.
Publicado: (2017)

p15(INK4B) is an alternative marker of senescent tumor cells in colorectal cancer
por: Park, Soon Sang, et al.
Publicado: (2023)

ZNF768 links oncogenic RAS to cellular senescence
por: Villot, Romain, et al.
Publicado: (2021)

Role of p16(INK4A) in Replicative Senescence and DNA Damage-Induced Premature Senescence in p53-Deficient Human Cells
por: Mirzayans, Razmik, et al.
Publicado: (2012)

Polycomb Mediated Epigenetic Silencing and Replication Timing at the INK4a/ARF Locus during Senescence
por: Agherbi, Hanane, et al.
Publicado: (2009)

Loss of p16(Ink4a) Function Rescues Cellular Senescence Induced by Telomere Dysfunction
por: Zhang, Xiufeng, et al.
Publicado: (2012)

MZF1 mediates oncogene-induced senescence by promoting the transcription of p16(INK4A)
por: Wu, Dan, et al.
Publicado: (2022)

Differential expression of tissue-restricted antigens among mTEC is associated with distinct autoreactive T cell fates
por: Lebel, Marie-Ève, et al.
Publicado: (2020)

The ICOS–ICOSL pathway tunes thymic selection
por: Dong, Mengqi, et al.
Publicado: (2022)

Sp1 Is Essential for p16(INK4a) Expression in Human Diploid Fibroblasts during Senescence
por: Wu, Junfeng, et al.
Publicado: (2007)

Cells exhibiting strong p16(INK4a) promoter activation in vivo display features of senescence
por: Liu, Jie-Yu, et al.
Publicado: (2019)

Dynamic Spatiotemporal Expression Pattern of the Senescence-Associated Factor p16Ink4a in Development and Aging
por: Safwan-Zaiter, Hasan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_du3edodmlrcam08cpivkv1njec