Systematic functional interrogation of human pseudogenes using CRISPRi

BACKGROUND: The human genome encodes over 14,000 pseudogenes that are evolutionary relics of protein-coding genes and commonly considered as nonfunctional. Emerging evidence suggests that some pseudogenes may exert important functions. However, to what extent human pseudogenes are functionally relev...

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Detalles Bibliográficos
Autores principales: Sun, Ming, Wang, Yunfei, Zheng, Caishang, Wei, Yanjun, Hou, Jiakai, Zhang, Peng, He, Wei, Lv, Xiangdong, Ding, Yao, Liang, Han, Hon, Chung-Chau, Chen, Xi, Xu, Han, Chen, Yiwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381491/
https://www.ncbi.nlm.nih.gov/pubmed/34425866
http://dx.doi.org/10.1186/s13059-021-02464-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381491/
https://www.ncbi.nlm.nih.gov/pubmed/34425866
http://dx.doi.org/10.1186/s13059-021-02464-2

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