Cargando…

Systematic functional interrogation of human pseudogenes using CRISPRi

BACKGROUND: The human genome encodes over 14,000 pseudogenes that are evolutionary relics of protein-coding genes and commonly considered as nonfunctional. Emerging evidence suggests that some pseudogenes may exert important functions. However, to what extent human pseudogenes are functionally relev...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, Ming, Wang, Yunfei, Zheng, Caishang, Wei, Yanjun, Hou, Jiakai, Zhang, Peng, He, Wei, Lv, Xiangdong, Ding, Yao, Liang, Han, Hon, Chung-Chau, Chen, Xi, Xu, Han, Chen, Yiwen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381491/ https://www.ncbi.nlm.nih.gov/pubmed/34425866 http://dx.doi.org/10.1186/s13059-021-02464-2

Ejemplares similares

CRISPR/Cas9 screen uncovers functional translation of cryptic lncRNA-encoded open reading frames in human cancer
por: Zheng, Caishang, et al.
Publicado: (2023)

Multiomics analyses reveal DARS1-AS1/YBX1–controlled posttranscriptional circuits promoting glioblastoma tumorigenesis/radioresistance
por: Zheng, Caishang, et al.
Publicado: (2023)

Integrated multi-omics analyses identify key anti-viral host factors and pathways controlling SARS-CoV-2 infection
por: Hou, Jiakai, et al.
Publicado: (2022)

An improved CRISPRi system in Pichia pastoris
por: Qiao, Shujing, et al.
Publicado: (2023)

Engineering Halomonas species TD01 for enhanced polyhydroxyalkanoates synthesis via CRISPRi
por: Tao, Wei, et al.
Publicado: (2017)

Pseudogenes in Cardiovascular Disease
por: Qi, Yanyan, et al.
Publicado: (2021)

Re-recognition of pseudogenes: From molecular to clinical applications
por: Chen, Xu, et al.
Publicado: (2020)

Pseudogenes
por: Tutar, Yusuf
Publicado: (2012)

A pseudogene-signature in glioma predicts survival
por: Gao, Kai-Ming, et al.
Publicado: (2015)

CRISPRi Gene Modulation and All-Optical Electrophysiology in Post-Differentiated Human iPSC-Cardiomyocytes
por: Han, Julie L., et al.
Publicado: (2023)

Targeted Modulation of Chicken Genes In Vitro Using CRISPRa and CRISPRi Toolkit
por: Chapman, Brittany, et al.
Publicado: (2023)

Multistable and dynamic CRISPRi-based synthetic circuits
por: Santos-Moreno, Javier, et al.
Publicado: (2020)

Transcriptional control of Clostridium autoethanogenum using CRISPRi
por: Fackler, Nicholas, et al.
Publicado: (2021)

Optimising PHBV biopolymer production in haloarchaea via CRISPRi-mediated redirection of carbon flux
por: Lin, Lin, et al.
Publicado: (2021)

Implications of pseudogenes for the prognosis of hepatocellular carcinoma
por: Liu, Zaoqu, et al.
Publicado: (2023)

A Study of Type II ɛ-PL Degrading Enzyme (pldII) in Streptomyces albulus through the CRISPRi System
por: Li, Qinyu, et al.
Publicado: (2022)

CircRNA-derived pseudogenes
por: Dong, Rui, et al.
Publicado: (2016)

Pseudogene.org: a comprehensive database and comparison platform for pseudogene annotation
por: Karro, John E., et al.
Publicado: (2007)

Corynebacterium glutamicum Metabolic Engineering with CRISPR Interference (CRISPRi)
por: Cleto, Sara, et al.
Publicado: (2016)

Enabling Genetic Analysis of Diverse Bacteria with Mobile-CRISPRi
por: Peters, Jason M., et al.
Publicado: (2019)

Robust and stable transcriptional repression in Giardia using CRISPRi
por: McInally, S. G., et al.
Publicado: (2019)

Combining CRISPRi and metabolomics for functional annotation of compound libraries
por: Anglada-Girotto, Miquel, et al.
Publicado: (2022)

Computational pipeline for designing guide RNAs for mismatch-CRISPRi
por: van Gestel, Jordi, et al.
Publicado: (2021)

Sequence-specific inhibition of microRNA via CRISPR/CRISPRi system
por: Zhao, Yicheng, et al.
Publicado: (2014)

The GENCODE pseudogene resource
por: Pei, Baikang, et al.
Publicado: (2012)

Pseudogenes in Human Cancer
por: Poliseno, Laura, et al.
Publicado: (2015)

Role of Pseudogenes in Tumorigenesis
por: Hu, Xinling, et al.
Publicado: (2018)

The human ABC transporter pseudogene family: Evidence for transcription and gene-pseudogene interference
por: Piehler, Armin P, et al.
Publicado: (2008)

A Special Phenotype of Aconidial Aspergillus niger SH2 and Its Mechanism of Formation via CRISPRi
por: Yu, Le-Yi, et al.
Publicado: (2022)

Specific Gene Repression by CRISPRi System Transferred through Bacterial Conjugation
por: Ji, Weiyue, et al.
Publicado: (2014)

Compositional characteristics of human peripheral TRBV pseudogene rearrangements
por: Shi, Bin, et al.
Publicado: (2018)

CRISPRi is not strand-specific at all loci and redefines the transcriptional landscape
por: Howe, Françoise S, et al.
Publicado: (2017)

Analysis of lipoprotein transport depletion in Vibrio cholerae using CRISPRi
por: Caro, Florence, et al.
Publicado: (2019)

Programmable Gene Knockdown in Diverse Bacteria Using Mobile‐CRISPRi
por: Banta, Amy B., et al.
Publicado: (2020)

dCas9 regulator to neutralize competition in CRISPRi circuits
por: Huang, Hsin-Ho, et al.
Publicado: (2021)

Targeted regulation of transcription in primary cells using CRISPRa and CRISPRi
por: Jensen, Trine I., et al.
Publicado: (2021)

Author Correction: Multistable and dynamic CRISPRi-based synthetic circuits
por: Santos-Moreno, Javier, et al.
Publicado: (2021)

An Integrative Synthetic Biology Approach to Interrogating Cellular Ubiquitin and Ufm Signaling
por: Li, Chuanyin, et al.
Publicado: (2020)

CRISPRi-Manipulation of Genetic Code Expansion via RF1 for Reassignment of Amber Codon in Bacteria
por: Zhang, Bo, et al.
Publicado: (2016)

Simultaneous Interrogation of Cancer Omics to Identify Subtypes With Significant Clinical Differences
por: Xu, Aodan, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ndv4rds01t79ra3nb5t42o57l7