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Systematic functional interrogation of human pseudogenes using CRISPRi

BACKGROUND: The human genome encodes over 14,000 pseudogenes that are evolutionary relics of protein-coding genes and commonly considered as nonfunctional. Emerging evidence suggests that some pseudogenes may exert important functions. However, to what extent human pseudogenes are functionally relev...

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Detalles Bibliográficos
Autores principales:	Sun, Ming, Wang, Yunfei, Zheng, Caishang, Wei, Yanjun, Hou, Jiakai, Zhang, Peng, He, Wei, Lv, Xiangdong, Ding, Yao, Liang, Han, Hon, Chung-Chau, Chen, Xi, Xu, Han, Chen, Yiwen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381491/ https://www.ncbi.nlm.nih.gov/pubmed/34425866 http://dx.doi.org/10.1186/s13059-021-02464-2

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