Cinobufagin-induced DNA damage response activates G(2)/M checkpoint and apoptosis to cause selective cytotoxicity in cancer cells

BACKGROUND: Processed extracts from toad skin and parotoid gland have long been used to treat various illnesses including cancer in many Asian countries. Recent studies have uncovered a family of bufadienolides as the responsible pharmacological compounds, and the two major molecules, cinobufagin an...

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Detalles Bibliográficos
Autores principales: Niu, Jiajing, Wang, Jiamei, Zhang, Qi, Zou, Zhihua, Ding, Yushuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381584/
https://www.ncbi.nlm.nih.gov/pubmed/34425836
http://dx.doi.org/10.1186/s12935-021-02150-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381584/
https://www.ncbi.nlm.nih.gov/pubmed/34425836
http://dx.doi.org/10.1186/s12935-021-02150-0

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