Unbiased proteomic mapping of the LINE-1 promoter using CRISPR Cas9

BACKGROUND: The autonomous retroelement Long Interspersed Element-1 (LINE-1) mobilizes though a copy and paste mechanism using an RNA intermediate (retrotransposition). Throughout human evolution, around 500,000 LINE-1 sequences have accumulated in the genome. Most of these sequences belong to ances...

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Detalles Bibliográficos
Autores principales: Briggs, Erica M., Mita, Paolo, Sun, Xiaoji, Ha, Susan, Vasilyev, Nikita, Leopold, Zev R., Nudler, Evgeny, Boeke, Jef D., Logan, Susan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381588/
https://www.ncbi.nlm.nih.gov/pubmed/34425899
http://dx.doi.org/10.1186/s13100-021-00249-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381588/
https://www.ncbi.nlm.nih.gov/pubmed/34425899
http://dx.doi.org/10.1186/s13100-021-00249-9

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