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Unbiased proteomic mapping of the LINE-1 promoter using CRISPR Cas9

BACKGROUND: The autonomous retroelement Long Interspersed Element-1 (LINE-1) mobilizes though a copy and paste mechanism using an RNA intermediate (retrotransposition). Throughout human evolution, around 500,000 LINE-1 sequences have accumulated in the genome. Most of these sequences belong to ances...

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Detalles Bibliográficos
Autores principales:	Briggs, Erica M., Mita, Paolo, Sun, Xiaoji, Ha, Susan, Vasilyev, Nikita, Leopold, Zev R., Nudler, Evgeny, Boeke, Jef D., Logan, Susan K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381588/ https://www.ncbi.nlm.nih.gov/pubmed/34425899 http://dx.doi.org/10.1186/s13100-021-00249-9

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