Cargando…

HIF1α is required for NK cell metabolic adaptation during virus infection

Natural killer (NK) cells are essential for early protection against virus infection and must metabolically adapt to the energy demands of activation. Here, we found upregulation of the metabolic adaptor hypoxia-inducible factor-1α (HIF1α) is a feature of mouse NK cells during murine cytomegalovirus...

Descripción completa

Detalles Bibliográficos
Autores principales:	Victorino, Francisco, Bigley, Tarin M, Park, Eugene, Yao, Cong-Hui, Benoit, Jeanne, Yang, Li-Ping, Piersma, Sytse J, Lauron, Elvin J, Davidson, Rebecca M, Patti, Gary J, Yokoyama, Wayne M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Immunology and Inflammation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382296/ https://www.ncbi.nlm.nih.gov/pubmed/34396954 http://dx.doi.org/10.7554/eLife.68484

Ejemplares similares

Virus infection is controlled by hematopoietic and stromal cell sensing of murine cytomegalovirus through STING
por: Piersma, Sytse J, et al.
Publicado: (2020)

The transcription factor Bach2 negatively regulates murine natural killer cell maturation and function
por: Li, Shasha, et al.
Publicado: (2022)

Dual Requirement of Cytokine and Activation Receptor Triggering for Cytotoxic Control of Murine Cytomegalovirus by NK Cells
por: Parikh, Bijal A., et al.
Publicado: (2015)

A herpesvirus encoded Qa-1 mimic inhibits natural killer cell cytotoxicity through CD94/NKG2A receptor engagement
por: Wang, Xiaoli, et al.
Publicado: (2018)

Toxoplasma gondii infection drives conversion of NK cells into ILC1-like cells
por: Park, Eugene, et al.
Publicado: (2019)

NK cell expansion requires HuR and mediates control of solid tumors and long-term virus infection
por: Piersma, Sytse J., et al.
Publicado: (2023)

Disruption of thymic central tolerance by infection with murine roseolovirus induces autoimmune gastritis
por: Bigley, Tarin M., et al.
Publicado: (2022)

SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies
por: Fielding, Ceri Alan, et al.
Publicado: (2022)

Single-cell transcriptome reveals the novel role of T-bet in suppressing the immature NK gene signature
por: Yang, Chao, et al.
Publicado: (2020)

Inhibition of SHP-1 activity by PKC-θ regulates NK cell activation threshold and cytotoxicity
por: Ben-Shmuel, Aviad, et al.
Publicado: (2022)

The transcription factor RUNX2 drives the generation of human NK cells and promotes tissue residency
por: Wahlen, Sigrid, et al.
Publicado: (2022)

Tumor control via targeting PD-L1 with chimeric antigen receptor modified NK cells
por: Robbins, Yvette, et al.
Publicado: (2020)

Single-cell profiling reveals periventricular CD56(bright) NK cell accumulation in multiple sclerosis
por: Rodríguez-Lorenzo, Sabela, et al.
Publicado: (2022)

Natural killer (NK) cell-derived extracellular-vesicle shuttled microRNAs control T cell responses
por: Dosil, Sara G, et al.
Publicado: (2022)

Viral MHCI inhibition evades tissue-resident memory T cell formation and responses
por: Lauron, Elvin J., et al.
Publicado: (2019)

NK cells inhibit Plasmodium falciparum growth in red blood cells via antibody-dependent cellular cytotoxicity
por: Arora, Gunjan, et al.
Publicado: (2018)

Icariin inhibits the inflammation through down-regulating NF-κB/HIF-2α signal pathways in chondrocytes
por: Wang, Pengzhen, et al.
Publicado: (2020)

Mitochondrial superoxide disrupts the metabolic and epigenetic landscape of CD4(+) and CD8(+) T-lymphocytes
por: Moshfegh, C.M., et al.
Publicado: (2019)

Influenza Vaccination Generates Cytokine-Induced Memory-like NK Cells: Impact of Human Cytomegalovirus Infection
por: Goodier, Martin R., et al.
Publicado: (2016)

IL-38 restrains inflammatory response of collagen-induced arthritis in rats via SIRT1/HIF-1α signaling pathway
por: Pei, Bing, et al.
Publicado: (2020)

IL-15 Promotes Polyfunctional NK Cell Responses to Influenza by Boosting IL-12 Production
por: Wagstaffe, Helen R., et al.
Publicado: (2018)

The mitochondrial iron transporter ABCB7 is required for B cell development, proliferation, and class switch recombination in mice
por: Lehrke, Michael Jonathan, et al.
Publicado: (2021)

Anti-inflammatory Treatment and Cardiovascular Outcomes: Results of Clinical Trials
por: Lorenzatti, Alberto J
Publicado: (2021)

Umbilical cord blood-derived ILC1-like cells constitute a novel precursor for mature KIR(+)NKG2A(-) NK cells
por: Bennstein, Sabrina Bianca, et al.
Publicado: (2020)

TAK1 protein kinase activity is required for TLR signalling and cytokine production in myeloid cells
por: Rodrigues, Melissa, et al.
Publicado: (2022)

Fine-tuning of β-catenin in mouse thymic epithelial cells is required for postnatal T-cell development
por: Fujimori, Sayumi, et al.
Publicado: (2022)

Cross-priming induces immunodomination in the presence of viral MHC class I inhibition
por: Lauron, Elvin J., et al.
Publicado: (2018)

Human NK Cells Lyse Th2-Polarizing Dendritic Cells via NKp30 and DNAM-1
por: Walwyn-Brown, Katherine, et al.
Publicado: (2018)

Chronic Ly49H Receptor Engagement in vivo Decreases NK Cell Response to Stimulation Through ITAM-Dependent and Independent Pathways Both in vitro and in vivo
por: Key, Phillip N., et al.
Publicado: (2019)

Differential Requirement for IRGM Proteins during Tuberculosis Infection in Mice
por: Wilburn, Kaley M., et al.
Publicado: (2023)

Long-term antigen exposure irreversibly modifies metabolic requirements for T cell function
por: Bettonville, Marie, et al.
Publicado: (2018)

SKAP2 is required for defense against K. pneumoniae infection and neutrophil respiratory burst
por: Nguyen, Giang T, et al.
Publicado: (2020)

Loss of GTPase activating protein neurofibromin stimulates paracrine cell communication via macropinocytosis
por: Ghoshal, Pushpankur, et al.
Publicado: (2019)

Role of Inflammation in Coronary Epicardial and Microvascular Dysfunction
por: Godo, Shigeo, et al.
Publicado: (2021)

Atherosclerotic Cardiovascular Disease in Rheumatoid Arthritis: Impact of Inflammation and Antirheumatic Treatment
por: Kerola, Anne Mirjam, et al.
Publicado: (2021)

The Role of C-reactive Protein in Patient Risk Stratification and Treatment
por: Arroyo-Espliguero, Ramón, et al.
Publicado: (2021)

Inflammation and Cardiovascular Disease: The Future
por: Arnold, Natalie, et al.
Publicado: (2021)

Small bowel stomas are associated with higher risk of circulating food-specific-IgG than patients with organic gastrointestinal conditions and colostomies
por: Carson, Walker K, et al.
Publicado: (2022)

Neonatal-derived IL-17 producing dermal γδ T cells are required to prevent spontaneous atopic dermatitis
por: Spidale, Nicholas A, et al.
Publicado: (2020)

Tuning of in vivo cognate B-T cell interactions by Intersectin 2 is required for effective anti-viral B cell immunity
por: Burbage, Marianne, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ov6r90ga6eftgt7l4qn679rg7j