Enhanced Activity of Exportin-1/CRM1 in Neurons Contributes to Autophagy Dysfunction and Senescent Features in Old Mouse Brain

Brain aging is characterized by dysfunctional autophagy and cellular senescence, among other features. While autophagy can either promote or suppress cellular senescence in proliferating cells, in postmitotic cells, such as neurons, autophagy impairment promotes cellular senescence. CRM1 (exportin-1...

Descripción completa

Detalles Bibliográficos
Autores principales: Gorostieta-Salas, Elisa, Moreno-Blas, Daniel, Gerónimo-Olvera, Cristian, Cisneros, Bulmaro, Court, Felipe A., Castro-Obregón, Susana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382534/
https://www.ncbi.nlm.nih.gov/pubmed/34434486
http://dx.doi.org/10.1155/2021/6682336

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382534/
https://www.ncbi.nlm.nih.gov/pubmed/34434486
http://dx.doi.org/10.1155/2021/6682336

Ejemplares similares