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Enhanced Activity of Exportin-1/CRM1 in Neurons Contributes to Autophagy Dysfunction and Senescent Features in Old Mouse Brain

Brain aging is characterized by dysfunctional autophagy and cellular senescence, among other features. While autophagy can either promote or suppress cellular senescence in proliferating cells, in postmitotic cells, such as neurons, autophagy impairment promotes cellular senescence. CRM1 (exportin-1...

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Detalles Bibliográficos
Autores principales:	Gorostieta-Salas, Elisa, Moreno-Blas, Daniel, Gerónimo-Olvera, Cristian, Cisneros, Bulmaro, Court, Felipe A., Castro-Obregón, Susana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382534/ https://www.ncbi.nlm.nih.gov/pubmed/34434486 http://dx.doi.org/10.1155/2021/6682336

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