Small Extracellular Vesicles Derived from Adipocytes Attenuate Intervertebral Disc Degeneration in Rats by Rejuvenating Senescent Nucleus Pulposus Cells and Endplate Cells by Delivering Exogenous NAMPT

Cellular senescence is a key factor in the development of intervertebral disc degeneration (IVDD). Age-associated decreases in NAD(+) levels play a critical role in regulating cellular senescence. Previous studies have found that small extracellular vesicles (sEVs) secreted by adipocytes (Adipo-sEVs...

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Detalles Bibliográficos
Autores principales: Sun, Yongjin, Li, Xu, Yang, Xiaoxu, Chen, Bi, Zhang, Wenzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382538/
https://www.ncbi.nlm.nih.gov/pubmed/34434488
http://dx.doi.org/10.1155/2021/9955448

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382538/
https://www.ncbi.nlm.nih.gov/pubmed/34434488
http://dx.doi.org/10.1155/2021/9955448

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