Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer’s disease

Aberrant inflammation in the central nervous system (CNS) has been implicated as a major player in the pathogenesis of human neurodegenerative disease. We developed a novel approach to derive microglia from human pluripotent stem cells (hPSCs) and built a defined hPSC-derived tri-culture system cont...

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Detalles Bibliográficos
Autores principales: Guttikonda, Sudha R., Sikkema, Lisa, Tchieu, Jason, Saurat, Nathalie, Walsh, Ryan, Harschnitz, Oliver, Ciceri, Gabriele, Sneeboer, Marjolein, Mazutis, Linas, Setty, Manu, Zumbo, Paul, Betel, Doron, de Witte, Lot D., Pe’er, Dana, Studer, Lorenz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382543/
https://www.ncbi.nlm.nih.gov/pubmed/33558694
http://dx.doi.org/10.1038/s41593-020-00796-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382543/
https://www.ncbi.nlm.nih.gov/pubmed/33558694
http://dx.doi.org/10.1038/s41593-020-00796-z

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