Current Progress and Perspectives on Using Gold Compounds for the Modulation of Tumor Cell Metabolism

Altered cellular metabolism, which is essential for the growth and survival of tumor cells in a specific microenvironment, is one of the hallmarks of cancer. Among the most significant changes in the metabolic pattern of tumor cells is the shift from oxidative phosphorylation to aerobic glycolysis f...

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Autores principales: Kou, Leiya, Wei, Shuang, Kou, Pei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382570/
https://www.ncbi.nlm.nih.gov/pubmed/34434922
http://dx.doi.org/10.3389/fchem.2021.733463
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author Kou, Leiya
Wei, Shuang
Kou, Pei
author_facet Kou, Leiya
Wei, Shuang
Kou, Pei
author_sort Kou, Leiya
collection PubMed
description Altered cellular metabolism, which is essential for the growth and survival of tumor cells in a specific microenvironment, is one of the hallmarks of cancer. Among the most significant changes in the metabolic pattern of tumor cells is the shift from oxidative phosphorylation to aerobic glycolysis for glucose utilization. Tumor cells also exhibit changes in patterns of protein and nucleic acid metabolism. Recently, gold compounds have been shown to target several metabolic pathways and a number of metabolites in tumor cells. In this review, we summarize how gold compounds modulate glucose, protein, and nucleic acid metabolism in tumor cells, resulting in anti-tumor effects. We also discuss the rationale underlying the anti-tumor effects of these gold compounds and highlight how to effectively utilize against various types of tumors.
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spelling pubmed-83825702021-08-24 Current Progress and Perspectives on Using Gold Compounds for the Modulation of Tumor Cell Metabolism Kou, Leiya Wei, Shuang Kou, Pei Front Chem Chemistry Altered cellular metabolism, which is essential for the growth and survival of tumor cells in a specific microenvironment, is one of the hallmarks of cancer. Among the most significant changes in the metabolic pattern of tumor cells is the shift from oxidative phosphorylation to aerobic glycolysis for glucose utilization. Tumor cells also exhibit changes in patterns of protein and nucleic acid metabolism. Recently, gold compounds have been shown to target several metabolic pathways and a number of metabolites in tumor cells. In this review, we summarize how gold compounds modulate glucose, protein, and nucleic acid metabolism in tumor cells, resulting in anti-tumor effects. We also discuss the rationale underlying the anti-tumor effects of these gold compounds and highlight how to effectively utilize against various types of tumors. Frontiers Media S.A. 2021-08-09 /pmc/articles/PMC8382570/ /pubmed/34434922 http://dx.doi.org/10.3389/fchem.2021.733463 Text en Copyright © 2021 Kou, Wei and Kou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Kou, Leiya
Wei, Shuang
Kou, Pei
Current Progress and Perspectives on Using Gold Compounds for the Modulation of Tumor Cell Metabolism
title Current Progress and Perspectives on Using Gold Compounds for the Modulation of Tumor Cell Metabolism
title_full Current Progress and Perspectives on Using Gold Compounds for the Modulation of Tumor Cell Metabolism
title_fullStr Current Progress and Perspectives on Using Gold Compounds for the Modulation of Tumor Cell Metabolism
title_full_unstemmed Current Progress and Perspectives on Using Gold Compounds for the Modulation of Tumor Cell Metabolism
title_short Current Progress and Perspectives on Using Gold Compounds for the Modulation of Tumor Cell Metabolism
title_sort current progress and perspectives on using gold compounds for the modulation of tumor cell metabolism
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382570/
https://www.ncbi.nlm.nih.gov/pubmed/34434922
http://dx.doi.org/10.3389/fchem.2021.733463
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