A SARS-CoV-2 antibody broadly neutralizes SARS-related coronaviruses and variants by coordinated recognition of a virus-vulnerable site

Potent neutralizing SARS-CoV-2 antibodies often target the spike protein receptor-binding site (RBS), but the variability of RBS epitopes hampers broad neutralization of multiple sarbecoviruses and drifted viruses. Here, using humanized mice, we identified an RBS antibody with a germline V(H) gene t...

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Detalles Bibliográficos
Autores principales: Onodera, Taishi, Kita, Shunsuke, Adachi, Yu, Moriyama, Saya, Sato, Akihiko, Nomura, Takao, Sakakibara, Shuhei, Inoue, Takeshi, Tadokoro, Takashi, Anraku, Yuki, Yumoto, Kohei, Tian, Cong, Fukuhara, Hideo, Sasaki, Michihito, Orba, Yasuko, Shiwa, Nozomi, Iwata, Naoko, Nagata, Noriyo, Suzuki, Tateki, Sasaki, Jiei, Sekizuka, Tsuyoshi, Tonouchi, Keisuke, Sun, Lin, Fukushi, Shuetsu, Satofuka, Hiroyuki, Kazuki, Yasuhiro, Oshimura, Mitsuo, Kurosaki, Tomohiro, Kuroda, Makoto, Matsuura, Yoshiharu, Suzuki, Tadaki, Sawa, Hirofumi, Hashiguchi, Takao, Maenaka, Katsumi, Takahashi, Yoshimasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382582/
https://www.ncbi.nlm.nih.gov/pubmed/34508662
http://dx.doi.org/10.1016/j.immuni.2021.08.025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382582/
https://www.ncbi.nlm.nih.gov/pubmed/34508662
http://dx.doi.org/10.1016/j.immuni.2021.08.025

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