Germline-Dependent Antibody Paratope States and Pairing Specific V(H)-V(L) Interface Dynamics

Antibodies have emerged as one of the fastest growing classes of biotherapeutic proteins. To improve the rational design of antibodies, we investigate the conformational diversity of 16 different germline combinations, which are composed of 4 different kappa light chains paired with 4 different heav...

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Detalles Bibliográficos
Autores principales: Fernández-Quintero, Monica L., Kroell, Katharina B., Bacher, Lisa M., Loeffler, Johannes R., Quoika, Patrick K., Georges, Guy, Bujotzek, Alexander, Kettenberger, Hubert, Liedl, Klaus R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382685/
https://www.ncbi.nlm.nih.gov/pubmed/34447370
http://dx.doi.org/10.3389/fimmu.2021.675655

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382685/
https://www.ncbi.nlm.nih.gov/pubmed/34447370
http://dx.doi.org/10.3389/fimmu.2021.675655

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