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Germline-Dependent Antibody Paratope States and Pairing Specific V(H)-V(L) Interface Dynamics
Antibodies have emerged as one of the fastest growing classes of biotherapeutic proteins. To improve the rational design of antibodies, we investigate the conformational diversity of 16 different germline combinations, which are composed of 4 different kappa light chains paired with 4 different heav...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382685/ https://www.ncbi.nlm.nih.gov/pubmed/34447370 http://dx.doi.org/10.3389/fimmu.2021.675655 |