Tau K321/K353 pseudoacetylation within KXGS motifs regulates tau–microtubule interactions and inhibits aggregation

Alzheimer’s disease is the leading cause of dementia and a defining hallmark is the progressive brain deposition of tau aggregates. The insidious accumulation of brain tau inclusions is also involved in a group of neurodegenerative diseases termed frontotemporal dementias. In all of these disorders,...

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Detalles Bibliográficos
Autores principales: Xia, Yuxing, Bell, Brach M., Giasson, Benoit I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382713/
https://www.ncbi.nlm.nih.gov/pubmed/34426645
http://dx.doi.org/10.1038/s41598-021-96627-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382713/
https://www.ncbi.nlm.nih.gov/pubmed/34426645
http://dx.doi.org/10.1038/s41598-021-96627-7

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