The Antibiotic Dosage of Fastest Resistance Evolution: Gene Amplifications Underpinning the Inverted-U

To determine the dosage at which antibiotic resistance evolution is most rapid, we treated Escherichia coli in vitro, deploying the antibiotic erythromycin at dosages ranging from zero to high. Adaptation was fastest just below erythromycin’s minimal inhibitory concentration (MIC) and genotype-pheno...

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Detalles Bibliográficos
Autores principales: Reding, Carlos, Catalán, Pablo, Jansen, Gunther, Bergmiller, Tobias, Wood, Emily, Rosenstiel, Phillip, Schulenburg, Hinrich, Gudelj, Ivana, Beardmore, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382913/
https://www.ncbi.nlm.nih.gov/pubmed/33693929
http://dx.doi.org/10.1093/molbev/msab025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382913/
https://www.ncbi.nlm.nih.gov/pubmed/33693929
http://dx.doi.org/10.1093/molbev/msab025

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