Modeling the Evolutionary Architectures of Transcribed Human Enhancer Sequences Reveals Distinct Origins, Functions, and Associations with Human Trait Variation

Despite the importance of gene regulatory enhancers in human biology and evolution, we lack a comprehensive model of enhancer evolution and function. This substantially limits our understanding of the genetic basis of species divergence and our ability to interpret the effects of noncoding variants...

Descripción completa

Detalles Bibliográficos
Autores principales: Fong, Sarah L, Capra, John A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382917/
https://www.ncbi.nlm.nih.gov/pubmed/33973014
http://dx.doi.org/10.1093/molbev/msab138

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382917/
https://www.ncbi.nlm.nih.gov/pubmed/33973014
http://dx.doi.org/10.1093/molbev/msab138

Ejemplares similares