Transient Depletion of Foxp3(+) Regulatory T Cells Selectively Promotes Aggressive β Cell Autoimmunity in Genetically Susceptible DEREG Mice

Type 1 diabetes (T1D) represents a hallmark of the fatal multiorgan autoimmune syndrome affecting humans with abrogated Foxp3(+) regulatory T (Treg) cell function due to Foxp3 gene mutations, but whether the loss of Foxp3(+) Treg cell activity is indeed sufficient to promote β cell autoimmunity requ...

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Detalles Bibliográficos
Autores principales: Watts, Deepika, Janßen, Marthe, Jaykar, Mangesh, Palmucci, Francesco, Weigelt, Marc, Petzold, Cathleen, Hommel, Angela, Sparwasser, Tim, Bonifacio, Ezio, Kretschmer, Karsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382961/
https://www.ncbi.nlm.nih.gov/pubmed/34447385
http://dx.doi.org/10.3389/fimmu.2021.720133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382961/
https://www.ncbi.nlm.nih.gov/pubmed/34447385
http://dx.doi.org/10.3389/fimmu.2021.720133

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