Cargando…

Transient Depletion of Foxp3(+) Regulatory T Cells Selectively Promotes Aggressive β Cell Autoimmunity in Genetically Susceptible DEREG Mice

Type 1 diabetes (T1D) represents a hallmark of the fatal multiorgan autoimmune syndrome affecting humans with abrogated Foxp3(+) regulatory T (Treg) cell function due to Foxp3 gene mutations, but whether the loss of Foxp3(+) Treg cell activity is indeed sufficient to promote β cell autoimmunity requ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Watts, Deepika, Janßen, Marthe, Jaykar, Mangesh, Palmucci, Francesco, Weigelt, Marc, Petzold, Cathleen, Hommel, Angela, Sparwasser, Tim, Bonifacio, Ezio, Kretschmer, Karsten
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382961/ https://www.ncbi.nlm.nih.gov/pubmed/34447385 http://dx.doi.org/10.3389/fimmu.2021.720133

Ejemplares similares

Advantages of Foxp3(+) regulatory T cell depletion using DEREG mice
por: Mayer, Christian T, et al.
Publicado: (2014)

Foxp3(+) Regulatory T Cells in Mouse Models of Type 1 Diabetes
por: Petzold, Cathleen, et al.
Publicado: (2013)

Optimal Isolation of Functional Foxp3(+) Induced Regulatory T Cells Using DEREG Mice
por: Baru, Abdul Mannan, et al.
Publicado: (2012)

Vagaries of Fluorochrome Reporter Gene Expression in Foxp3(+) Regulatory T Cells
por: Schallenberg, Sonja, et al.
Publicado: (2012)

Inducible IL-7 Hyperexpression Influences Lymphocyte Homeostasis and Function and Increases Allograft Rejection
por: Schreiber, Maria, et al.
Publicado: (2019)

Rapid Rebound of the Treg Compartment in DEREG Mice Limits the Impact of Treg Depletion on Mycobacterial Burden, but Prevents Autoimmunity
por: Berod, Luciana, et al.
Publicado: (2014)

Hypoxia signaling pathway: A central mediator in endocrine tumors
por: Watts, Deepika, et al.
Publicado: (2023)

Selective depletion of Foxp3(+) regulatory T cells induces a scurfy-like disease
por: Lahl, Katharina, et al.
Publicado: (2007)

Repeated Long-Term DT Application in the DEREG Mouse Induces a Neutralizing Anti-DT Antibody Response
por: Wang, Junhua, et al.
Publicado: (2016)

Identification of an immediate Foxp3(−) precursor to Foxp3(+) regulatory T cells in peripheral lymphoid organs of nonmanipulated mice
por: Schallenberg, Sonja, et al.
Publicado: (2010)

Foxp3(+) Regulatory T Cells in Bone and Hematopoietic Homeostasis
por: Fischer, Luise, et al.
Publicado: (2019)

Antigen receptor-mediated depletion of FOXP3 in induced regulatory T-lymphocytes via PTPN2 and FOXO1
por: Bothur, Evita, et al.
Publicado: (2015)

Foxp3(+) Regulatory T Cells Control Persistence of Viral CNS Infection
por: Reuter, Dajana, et al.
Publicado: (2012)

Targeting DEC-205(−)DCIR2(+) dendritic cells promotes immunological tolerance in proteolipid protein-induced experimental autoimmune encephalomyelitis
por: Tabansky, Inna, et al.
Publicado: (2018)

Transient anxiety-and depression-like behaviors are linked to the depletion of Foxp3-expressing cells via inflammasome in the brain
por: Yang, Eun-Jeong, et al.
Publicado: (2023)

Foxp3 expression is associated with aggressiveness in differentiated thyroid carcinomas
por: Cunha, Lucas Leite, et al.
Publicado: (2012)

Regulatory CD4(+)Foxp3(+) T Cells Control the Severity of Anaphylaxis
por: Kanjarawi, Reem, et al.
Publicado: (2013)

Critical Role of TGF-β and IL-2 Receptor Signaling in Foxp3 Induction by an Inhibitor of DNA Methylation
por: Freudenberg, Kristin, et al.
Publicado: (2018)

Role of Dynamic Actin Cytoskeleton Remodeling in Foxp3(+) Regulatory T Cell Development and Function: Implications for Osteoclastogenesis
por: Dohnke, Sebastian, et al.
Publicado: (2022)

Rapamycin Monotherapy in Patients With Type 1 Diabetes Modifies CD4(+)CD25(+)FOXP3(+) Regulatory T-Cells
por: Monti, Paolo, et al.
Publicado: (2008)

Severe Developmental B Lymphopoietic Defects in Foxp3-Deficient Mice are Refractory to Adoptive Regulatory T Cell Therapy
por: Riewaldt, Julia, et al.
Publicado: (2012)

Depleting T regulatory cells by targeting intracellular Foxp3 with a TCR mimic antibody
por: Dao, Tao, et al.
Publicado: (2019)

Foxp3(+) Regulatory T Cells Are Required for Recovery from Severe Sepsis
por: Kühlhorn, Franziska, et al.
Publicado: (2013)

FOXP3 Allelic Variants and Haplotype Structures Are Associated with Aggressive Breast Cancer Subtypes
por: Banin Hirata, Bruna Karina, et al.
Publicado: (2017)

Serotonin Depletion-Induced Maladaptive Aggression Requires the Presence of Androgens
por: Studer, Erik, et al.
Publicado: (2015)

Schistosoma mansoni-Mediated Suppression of Allergic Airway Inflammation Requires Patency and Foxp3(+) Treg Cells
por: Layland, Laura E., et al.
Publicado: (2013)

Depletion of Foxp3(+) regulatory T cells is accompanied by an increase in the relative abundance of Firmicutes in the murine gut microbiome
por: Kehrmann, Jan, et al.
Publicado: (2019)

Polycomb deficiency drives a FOXP2-high aggressive state targetable by epigenetic inhibitors
por: Chen, Fan, et al.
Publicado: (2023)

Intergenerational Transmission of Peer Aggression
por: Wiertsema, Maria, et al.
Publicado: (2022)

Antibody-based depletion of Foxp3+ T cells potentiates antitumor immune memory stimulated by mTOR inhibition
por: Kim, Hyung L
Publicado: (2014)

FoxP3+ Regulatory T Cells Determine Disease Severity in Rodent Models of Inflammatory Neuropathies
por: Meyer zu Hörste, Gerd, et al.
Publicado: (2014)

Absence of Foxp3(+) Regulatory T Cells during Allergen Provocation Does Not Exacerbate Murine Allergic Airway Inflammation
por: Baru, Abdul Mannan, et al.
Publicado: (2012)

The Impact of Bodily States on Divergent Thinking: Evidence for a Control-Depletion Account
por: Zhou, Yanyun, et al.
Publicado: (2017)

Depletion of Foxp3(+) regulatory T cells augments CD4(+) T cell immune responses in atherosclerosis-prone hypercholesterolemic mice
por: Kasahara, Kazuyuki, et al.
Publicado: (2022)

Neuropilin 1 deficiency on CD4(+)Foxp3(+) regulatory T cells impairs mouse melanoma growth
por: Hansen, Wiebke, et al.
Publicado: (2012)

Extracellular NAD(+) shapes the Foxp3(+) regulatory T cell compartment through the ART2–P2X7 pathway
por: Hubert, Sandra, et al.
Publicado: (2010)

IL-1α Mediated Chorioamnionitis Induces Depletion of FoxP3+ Cells and Ileal Inflammation in the Ovine Fetal Gut
por: Wolfs, Tim G. A. M., et al.
Publicado: (2011)

FOXP2
por: Nudel, Ron, et al.
Publicado: (2013)

Adenosine Depletion as A New Strategy to Decrease Glioblastoma Stem-Like Cells Aggressiveness
por: Niechi, Ignacio, et al.
Publicado: (2019)

Temozolomide abrogates the aggressiveness of urothelial carcinoma cells by enhancing senescence and depleting the side population
por: Kim, Na-Yon, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_vro8ehkm5o4pb1dh86riu7oqpv