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Dysregulated Microglial Cell Activation and Proliferation Following Repeated Antigen Stimulation
Upon reactivation of quiescent neurotropic viruses antigen (Ag)-specific brain resident-memory CD8+ T-cells (bT(RM)) may respond to de novo-produced viral Ag through the rapid release of IFN-γ, which drives subsequent interferon-stimulated gene expression in surrounding microglia. Through this mecha...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383069/ https://www.ncbi.nlm.nih.gov/pubmed/34447297 http://dx.doi.org/10.3389/fncel.2021.686340 |