Swainsonine Triggers Paraptosis via ER Stress and MAPK Signaling Pathway in Rat Primary Renal Tubular Epithelial Cells

Swainsonine (SW), an indolizidine alkaloid extracted from locoweeds, was shown toxic effects in multiple studies, but the underlying action mechanism remains unclear. SW is known to cause autophagy and apoptosis, but there has been no report on paraptosis mediated cell death. Here, we showed that SW...

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Detalles Bibliográficos
Autores principales: Wang, Shuai, Guo, Yazhou, Yang, Chen, Huang, Ruijie, Wen, Yuting, Zhang, Chunyan, Wu, Chenchen, Zhao, Baoyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383073/
https://www.ncbi.nlm.nih.gov/pubmed/34447312
http://dx.doi.org/10.3389/fphar.2021.715285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383073/
https://www.ncbi.nlm.nih.gov/pubmed/34447312
http://dx.doi.org/10.3389/fphar.2021.715285

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