Adult-born proopiomelanocortin neurons derived from Rax-expressing precursors mitigate the metabolic effects of congenital hypothalamic proopiomelanocortin deficiency

OBJECTIVE: Proopiomelanocortin (POMC) neurons of the hypothalamic arcuate nucleus are essential regulators of energy balance. Selective loss of POMC production in these cells results in extreme obesity and metabolic comorbidities. Neurogenesis occurs in the adult hypothalamus, but it remains uncerta...

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Detalles Bibliográficos
Autores principales: Surbhi, Wittmann, Gábor, Low, Malcolm J., Lechan, Ronald M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383116/
https://www.ncbi.nlm.nih.gov/pubmed/34329773
http://dx.doi.org/10.1016/j.molmet.2021.101312

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383116/
https://www.ncbi.nlm.nih.gov/pubmed/34329773
http://dx.doi.org/10.1016/j.molmet.2021.101312

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