Cargando…

Adult-born proopiomelanocortin neurons derived from Rax-expressing precursors mitigate the metabolic effects of congenital hypothalamic proopiomelanocortin deficiency

OBJECTIVE: Proopiomelanocortin (POMC) neurons of the hypothalamic arcuate nucleus are essential regulators of energy balance. Selective loss of POMC production in these cells results in extreme obesity and metabolic comorbidities. Neurogenesis occurs in the adult hypothalamus, but it remains uncerta...

Descripción completa

Detalles Bibliográficos
Autores principales:	Surbhi, Wittmann, Gábor, Low, Malcolm J., Lechan, Ronald M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383116/ https://www.ncbi.nlm.nih.gov/pubmed/34329773 http://dx.doi.org/10.1016/j.molmet.2021.101312

Ejemplares similares

Unraveling the Central Proopiomelanocortin Neural Circuits
por: Mercer, Aaron J., et al.
Publicado: (2013)

Proopiomelanocortin (POMC) and psychodermatology
por: Millington, George W. M., et al.
Publicado: (2023)

Hypothalamic Proopiomelanocortin Is Necessary for Normal Glucose Homeostasis in Female Mice
por: Alsina, Ramiro, et al.
Publicado: (2018)

The role of proopiomelanocortin (POMC) neurones in feeding behaviour
por: Millington, George WM
Publicado: (2007)

Relative Number and Distribution of Murine Hypothalamic Proopiomelanocortin Neurons Innervating Distinct Target Sites
por: King, Connie M., et al.
Publicado: (2011)

Adrenalectomy stimulates hypothalamic proopiomelanocortin expression but does not correct diet-induced obesity
por: Makimura, Hideo, et al.
Publicado: (2003)

A Patient with Proopiomelanocortin Deficiency: An Increasingly Important Diagnosis to Make
por: Çetinkaya, Semra, et al.
Publicado: (2018)

Estradiol Drives the Anorexigenic Activity of Proopiomelanocortin Neurons in Female Mice
por: Stincic, Todd L., et al.
Publicado: (2018)

Molecular evolution of the proopiomelanocortin system in Barn owl species
por: Löw, Karin, et al.
Publicado: (2020)

Endocannabinoid Signaling at Hypothalamic Steroidogenic Factor-1/Proopiomelanocortin Synapses Is Sex- and Diet-Sensitive
por: Fabelo, Carolina, et al.
Publicado: (2018)

OR16-03 Metabolic Effects Of Hypothalamic Pomc Neurons Generated Postnatally From Tanycytes On A Pomc Null Genetic Background
por: Gahlot, Surbhi, et al.
Publicado: (2020)

Posttranslational Modifications of Proopiomelanocortin in Vertebrates and Their Biological Significance
por: Takahashi, Akiyoshi, et al.
Publicado: (2013)

Ancient Exaptation of a CORE-SINE Retroposon into a Highly Conserved Mammalian Neuronal Enhancer of the Proopiomelanocortin Gene
por: Santangelo, Andrea M, et al.
Publicado: (2007)

Trilogy Development of Proopiomelanocortin Neurons From Embryonic to Adult Stages in the Mice Retina
por: Zhang, Xuhong, et al.
Publicado: (2021)

Newcastle disease virus-infected splenocytes express the proopiomelanocortin gene
Publicado: (1986)

Biomimetic proopiomelanocortin suppresses capsaicin-induced sensory irritation in humans
por: Fatemi, Sayed Ali, et al.
Publicado: (2016)

Serum kisspeptin and proopiomelanocortin in cystic fibrosis: a single study
por: Galiniak, Sabina, et al.
Publicado: (2022)

Reelin is modulated by diet-induced obesity and has direct actions on arcuate proopiomelanocortin neurons
por: Roberts, Brandon L., et al.
Publicado: (2019)

Female Mice Lacking Estrogen Receptor-α in Hypothalamic Proopiomelanocortin (POMC) Neurons Display Enhanced Estrogenic Response on Cortical Bone Mass
por: Farman, H. H., et al.
Publicado: (2016)

Disrupted erythropoietin signaling promotes obesity and alters hypothalamus proopiomelanocortin production
por: Teng, Ruifeng, et al.
Publicado: (2011)

Peripheral mechanisms contributing to the glucocorticoid hypersensitivity in proopiomelanocortin null mice treated with corticosterone
por: Michailidou, Zoi, et al.
Publicado: (2007)

Proopiomelanocortin, glucocorticoid, and CRH receptor expression in human ACTH-secreting pituitary adenomas
por: Cassarino, Maria Francesca, et al.
Publicado: (2016)

Two Cases With an Early Presented Proopiomelanocortin Deficiency—A Long-Term Follow-Up and Systematic Literature Review
por: Gregoric, Nadan, et al.
Publicado: (2021)

Leukemia Inhibitory Factor Induces Proopiomelanocortin via CRH/CRHR Pathway in Mouse Trophoblast
por: Wang, He, et al.
Publicado: (2021)

Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice
por: Matsushita, Yuki, et al.
Publicado: (2016)

Reported Benefits of Low-Dose Naltrexone Appear to Be Independent of the Endogenous Opioid System Involving Proopiomelanocortin Neurons and β-Endorphin
por: Metz, Marissa J., et al.
Publicado: (2021)

Effects of Variants in Proopiomelanocortin and Neuropeptide Y Genes on Growth, Carcass, and Meat Quality Traits in Rabbits
por: Liu, Wen-Chao, et al.
Publicado: (2014)

Sex-Determining Region Y Controls the Effects of Fetal Alcohol Exposure on Proopiomelanocortin Gene Expression
por: Gangisetty, Omkaram, et al.
Publicado: (2021)

Fetal Alcohol Exposure Alters Proopiomelanocortin Gene Expression and Hypothalamic-Pituitary-Adrenal Axis Function via Increasing MeCP2 Expression in the Hypothalamus
por: Gangisetty, Omkaram, et al.
Publicado: (2014)

Selective Restoration of Pomc Expression in Glutamatergic POMC Neurons: Evidence for a Dynamic Hypothalamic Neurotransmitter Network
por: Jones, Graham L., et al.
Publicado: (2019)

5-HT inhibition of rat insulin 2 promoter Cre recombinase transgene and proopiomelanocortin neuron excitability in the mouse arcuate nucleus
por: Hisadome, K., et al.
Publicado: (2009)

Corrigendum: Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice
por: Matsushita, Yuki, et al.
Publicado: (2016)

LBODP109 Astrocytes Affect The Metabolism Of Proopiomelanocortin (pomc) Neurons Through The Release Of Exosomes That Are Modified In A Fatty Acid Specific Manner
por: Collado-Pérez, Roberto, et al.
Publicado: (2022)

Mild exercise suppresses exacerbation of dermatitis by increasing cleavage of the β-endorphin from proopiomelanocortin in NC/Nga mice
por: Hiramoto, Keiichi, et al.
Publicado: (2013)

The Role of Proopiomelanocortin and α-Melanocyte-Stimulating Hormone in the Metabolic Syndrome in Psychiatric Disorders: A Narrative Mini-Review
por: Raue, Stefan, et al.
Publicado: (2019)

Targeting the TR4 nuclear receptor with antagonist bexarotene can suppress the proopiomelanocortin signalling in AtT‐20 cells
por: Xia, Liqun, et al.
Publicado: (2021)

Differential Effects of Fkbp4 and Fkbp5 on Regulation of the Proopiomelanocortin Gene in Murine AtT-20 Corticotroph Cells
por: Kageyama, Kazunori, et al.
Publicado: (2021)

The vital role of arcuate nociceptin/orphanin FQ neurones in mounting an oestradiol‐dependent adaptive response to negative energy balance via inhibition of nearby proopiomelanocortin neurones
por: Sayers, Sarah, et al.
Publicado: (2022)

Glucose Intake Alters Expression of Neuropeptides Derived from Proopiomelanocortin in the Lateral Hypothalamus and the Nucleus Accumbens in Fructose Preference Rats
por: Jiao, Guangfa, et al.
Publicado: (2017)

DNA methylation and expression of proopiomelanocortin (POMC) gene in the hypothalamus of three‐week‐old chickens show sex‐specific differences
por: Rancourt, Rebecca C., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_npuhgbn9c0fth85g2ovv3sgq7l