Cargando…

Sex-Specific Association of the X Chromosome With Cognitive Change and Tau Pathology in Aging and Alzheimer Disease

IMPORTANCE: The X chromosome represents 5% of the human genome in women and men, and its influence on cognitive aging and Alzheimer disease (AD) is largely unknown. OBJECTIVE: To determine whether the X chromosome is associated with sex-specific cognitive change and tau pathology in aging and AD. DE...

Descripción completa

Detalles Bibliográficos
Autores principales:	Davis, Emily J., Solsberg, Caroline W., White, Charles C., Miñones-Moyano, Elena, Sirota, Marina, Chibnik, Lori, Bennett, David A., De Jager, Philip L., Yokoyama, Jennifer S., Dubal, Dena B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Medical Association 2021
Materias:	Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383157/ https://www.ncbi.nlm.nih.gov/pubmed/34424272 http://dx.doi.org/10.1001/jamaneurol.2021.2806

Ejemplares similares

Sex-Stratified Single-Cell RNA-Seq Analysis Identifies Sex-Specific and Cell Type-Specific Transcriptional Responses in Alzheimer’s Disease Across Two Brain Regions
por: Belonwu, Stella A., et al.
Publicado: (2021)

Deep phenotyping of Alzheimer’s disease leveraging electronic medical records identifies sex-specific clinical associations
por: Tang, Alice S., et al.
Publicado: (2022)

Female XX sex chromosomes increase survival and extend lifespan in aging mice
por: Davis, Emily J., et al.
Publicado: (2018)

Sex and gonadal hormones in mouse models of Alzheimer’s disease: what is relevant to the human condition?
por: Dubal, Dena B, et al.
Publicado: (2012)

Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer’s disease
por: Patrick, Ellis, et al.
Publicado: (2017)

A cortical immune network map identifies distinct microglial transcriptional programs associated with β-amyloid and Tau pathologies
por: Patrick, Ellis, et al.
Publicado: (2021)

Human P301L-Mutant Tau Expression in Mouse Entorhinal-Hippocampal Network Causes Tau Aggregation and Presynaptic Pathology but No Cognitive Deficits
por: Harris, Julie A., et al.
Publicado: (2012)

Intermediate Phenotypes Identify Divergent Pathways to Alzheimer's Disease
por: Shulman, Joshua M., et al.
Publicado: (2010)

Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease
por: Bryant, Annie G., et al.
Publicado: (2020)

Alzheimer’s loci: epigenetic associations and interaction with genetic factors
por: Chibnik, Lori B, et al.
Publicado: (2015)

Diurnal and seasonal molecular rhythms in human neocortex and their relation to Alzheimer's disease
por: Lim, Andrew S. P., et al.
Publicado: (2017)

Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice
por: Guo, Jing L., et al.
Publicado: (2016)

Structure and Pathology of Tau Protein in Alzheimer Disease
por: Kolarova, Michala, et al.
Publicado: (2012)

Microglia in Alzheimer’s Disease in the Context of Tau Pathology
por: Perea, Juan Ramón, et al.
Publicado: (2020)

Impact of Tau on Neurovascular Pathology in Alzheimer's Disease
por: Canepa, Elisa, et al.
Publicado: (2021)

Alzheimer's Disease: Tau Pathology and Dysfunction of Endocytosis
por: Ando, Kunie, et al.
Publicado: (2021)

Tau Activates Transposable Elements in Alzheimer’s Disease
por: Guo, Caiwei, et al.
Publicado: (2018)

Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau
por: Lasagna-Reeves, Cristian A., et al.
Publicado: (2012)

Phospho-Tau and Cognitive Decline in Alzheimer's Disease. Commentary: Tau in physiology and pathology
por: DeFelipe, Javier
Publicado: (2016)

Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain
por: DeVos, Sarah L., et al.
Publicado: (2018)

PHF-Core Tau as the Potential Initiating Event for Tau Pathology in Alzheimer’s Disease
por: Luna-Viramontes, Nabil Itzi, et al.
Publicado: (2020)

Staging tau pathology with tau PET in Alzheimer’s disease: a longitudinal study
por: Chen, Shi-Dong, et al.
Publicado: (2021)

Impact of the X Chromosome and sex on regulatory variation
por: Kukurba, Kimberly R., et al.
Publicado: (2016)

PET Imaging of Tau Pathology in Alzheimer’s Disease and Tauopathies
por: James, Olga G., et al.
Publicado: (2015)

The Dichotomy of Alzheimer’s Disease Pathology: Amyloid-β and Tau
por: Ashford, J. Wesson
Publicado: (2019)

The Role of Copper in Tau-Related Pathology in Alzheimer’s Disease
por: Zubčić, Klara, et al.
Publicado: (2020)

Cerebrovascular disease promotes tau pathology in Alzheimer’s disease
por: Laing, Krystal K, et al.
Publicado: (2020)

The role of pathological tau in synaptic dysfunction in Alzheimer’s diseases
por: Wu, Moxin, et al.
Publicado: (2021)

A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer’s disease
por: Mostafavi, Sara, et al.
Publicado: (2018)

Sex Chromosomes and Gonads Shape the Sex-Biased Transcriptomic Landscape in Tlr7-Mediated Demyelination During Aging
por: Lopez-Lee, Chloe, et al.
Publicado: (2023)

Female Resilience in Brain Aging
por: Dubal, Dena
Publicado: (2021)

Absence of a Role for Phosphorylation in the Tau Pathology of Alzheimer’s Disease
por: Lai, Robert Y. K., et al.
Publicado: (2016)

Tau Pathology of Alzheimer Disease: Possible Role of Sleep Deprivation
por: Ahmadian, Nahid, et al.
Publicado: (2018)

In vivo coupling of tau pathology and cortical thinning in Alzheimer's disease
por: Mak, Elijah, et al.
Publicado: (2018)

Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer's disease
por: Arnsten, Amy F. T., et al.
Publicado: (2020)

Dendritic/Post-synaptic Tau and Early Pathology of Alzheimer’s Disease
por: Yin, Xiaomin, et al.
Publicado: (2021)

Heterogeneous distribution of tau pathology in the behavioural variant of Alzheimer’s disease
por: Singleton, Ellen, et al.
Publicado: (2021)

CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer’s disease
por: Horie, Kanta, et al.
Publicado: (2023)

The X Files: “The Mystery of X Chromosome Instability in Alzheimer’s Disease”
por: Bajic, Vladan P., et al.
Publicado: (2020)

X chromosome aneuploidy in the Alzheimer’s disease brain
por: Yurov, Yuri B, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_hhgmlaqi6a1gfb9eif0gpvfh8m