Stereoselective Installation of Five Contiguous Stereogenic Centers in a Double Aldol–Tishchenko Cascade and Evaluation of the Key Transition State through DFT Calculation

[Image: see text] The stereoselective formation of 5 contiguous chiral centers in a single pot reaction is demonstrated using an aldol, aldol–Tishchenko reaction of N-tert-butyl sulfinimines. One diastereoisomer (from 32 possibilities) predominates, and a series of cyclic and acyclic 3-amino-1,5-dio...

Descripción completa

Detalles Bibliográficos
Autores principales: Mackey, Pamela, Turlik, Aneta, Ando, Kaori, Light, Mark E., Houk, K. N., McGlacken, Gerard P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383304/
https://www.ncbi.nlm.nih.gov/pubmed/34374288
http://dx.doi.org/10.1021/acs.orglett.1c02179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383304/
https://www.ncbi.nlm.nih.gov/pubmed/34374288
http://dx.doi.org/10.1021/acs.orglett.1c02179

Ejemplares similares