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Stereoselective Installation of Five Contiguous Stereogenic Centers in a Double Aldol–Tishchenko Cascade and Evaluation of the Key Transition State through DFT Calculation

[Image: see text] The stereoselective formation of 5 contiguous chiral centers in a single pot reaction is demonstrated using an aldol, aldol–Tishchenko reaction of N-tert-butyl sulfinimines. One diastereoisomer (from 32 possibilities) predominates, and a series of cyclic and acyclic 3-amino-1,5-dio...

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Detalles Bibliográficos
Autores principales:	Mackey, Pamela, Turlik, Aneta, Ando, Kaori, Light, Mark E., Houk, K. N., McGlacken, Gerard P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383304/ https://www.ncbi.nlm.nih.gov/pubmed/34374288 http://dx.doi.org/10.1021/acs.orglett.1c02179

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