Neuronal VCP loss of function recapitulates FTLD-TDP pathology

The pathogenic mechanism by which dominant mutations in VCP cause multisystem proteinopathy (MSP), a rare neurodegenerative disease that presents as fronto-temporal lobar degeneration with TDP-43 inclusions (FTLD-TDP), remains unclear. To explore this, we inactivate VCP in murine postnatal forebrain...

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Detalles Bibliográficos
Autores principales: Wani, Abubakar, Zhu, Jiang, Ulrich, Jason D., Eteleeb, Abdallah, Sauerbeck, Andrew D., Reitz, Sydney J., Arhzaouy, Khalid, Ikenaga, Chiseko, Yuede, Carla M., Pittman, Sara K., Wang, Feng, Li, Shan, Benitez, Bruno A., Cruchaga, Carlos, Kummer, Terrance T., Harari, Oscar, Chou, Tsui-Fen, Schröder, Rolf, Clemen, Christoph S., Weihl, Conrad C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383344/
https://www.ncbi.nlm.nih.gov/pubmed/34289347
http://dx.doi.org/10.1016/j.celrep.2021.109399

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383344/
https://www.ncbi.nlm.nih.gov/pubmed/34289347
http://dx.doi.org/10.1016/j.celrep.2021.109399

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